A total of 561 cases of cardiac failure events were associated with BNT162b2 (ROR 2.60, 95% CI 2.37–2.86, height 8.95), ranked by the absolute number of cases including congestive cardiac failure (ROR 2.91, 95% CI 2.29–3.68, height 3.55, 92 cases), pulmonary edema (ROR 1.77, 95% CI 1.40–2.23, height 3.60, 85 cases), and increased brain natriuretic peptide (ROR 4.23, 95% CI 3.18–5.61, height 2.96, 72 cases). Here, NPPB is linked to heart failure.