Conversely, in neuromyelitis optica spectrum disorder associated with antibodies to the aquaporin-4 water channel (AQP4+NMOSD), and in myelin oligodendrocyte glycoprotein-IgG associated disease (MOGAD), neurological deficits are mainly the result of incomplete recovery from clinical attacks, with a more favorable outcome generally observed in patients with MOGAD. Here, AQP4 is linked to neuromyelitis optica.