DES and nemaline myopathy: Examples include Desmin Myopathy which is characterized by abnormal aggregates of desmin-type intermediate filaments in the skeletal, cardiac, and rarely the intestinal smooth muscle, Nemaline Myopathy (NM) is a rare, genetically heterogeneous, autosomal dominant, or recessive myopathy due to mutations in the alpha-actin, alpha-tropomyosin or nebulin gene, and Central Core Disease (CCD).