In HCC, certain spliceosomal components are dysregulated and associated with liver oncogenesis, such as SF3B1, SRSF3, ESRP2 or MBNL318; however, the expression profile of key spliceosome components and splicing factors has been only superficially explored in HCC.19, 20, 21. Here, ESRP2 is linked to hepatocellular carcinoma.