In addition, TCGA data also indicated that HCC is frequently associated with genomic alterations of these spliceosomal components (Figure S1C), including EIF4A3, RBM3, ESRP2 and SRPK1, which were altered in a 5%, 1.9%, 1.1% and 1.9% of the patients, respectively (Figure 1F). This evidence concerns the gene SRPK1 and hepatocellular carcinoma.