Interestingly, TUNEL‐positive cells were only detected in neurons following cerebral I/R injury, while neither GFAP‐positive astrocytes nor Iba‐1‐positive microglia showed any TUNEL immunoreactivity, indicating that neurons are the most sensitive cell type in the ischemic brain and RIPC reduces ischemia‐induced neuronal apoptosis. Here, AIF1 is linked to ischemia.