In a study of parasite transcripts from 45 children, expression of var genes predicted to bind to EPCR but not ICAM-1 was associated with severe malaria but not with cerebral malaria or severe malaria anaemia alone, whereas transcription of var genes encoding both ICAM-1 and EPCR binding was associated specifically with cerebral malaria [124]. This evidence concerns the gene ICAM1 and anemia.