Interestingly, in another small cohort, total IgG targeting full length DC13 (which is dual ICAM-1 and EPCR binding) was boosted in individuals with uncomplicated malaria from presentation to convalescence, whereas IgG1 and IgG3 to this protein were boosted in convalescence from cerebral malaria [259]. The gene discussed is ICAM1; the disease is cerebral malaria.