Furthermore, deletion of nitric oxide synthase 2 (Nos2) or Casp8, another key molecule in PANoptosis, reduces SARS-CoV-2 infection-driven weight loss without impacting peak viral burdens in mice, suggesting there may be a pathogenic role for the iNOS-caspase-8 axis in COVID-19 [160]. Here, NOS2 is linked to COVID-19.