Besides, the expression of MMPs, tissue inhibitor of matrix metalloproteinase (TIMPs), RhoA, Rac1, ROCK1 and ROCK2 also progressively increase with the gradual increase of matrix stiffness from 6 to 135 kPa in human salivary adenoid cystic carcinoma cells, implying that RhoA/ROCK pathway may be a potential mechanism by which matrix stiffness promotes tumor cell migration and invasion [73]. The gene discussed is RHOA; the disease is neoplasm.