Recent study has found that C-X-C chemokine receptor type 4 (CXCR4) acts as a key protein in the interaction of molecular switch and matrix stiffness signaling, and controls HCC cell growth through YAP signaling pathway, further demonstrating that increasing matrix stiffness promotes the proliferative activity of HCC [61]. The gene discussed is CXCR4; the disease is hepatocellular carcinoma.