CXCR1 and neoplasm: So, according to the TANs' role in tumor metastasis and angiogenesis, some therapeutic methods targeting TANs were suggested, with two basic approaches: (a) targeting the CXCL-8/CXCR-1/CXCR-2 axis to block TANs, or (b) targeting substances released by polymorpho-nuclear cells that stimulate cancer growth [104].