TP53 and tubular adenoma: Interestingly, a tubular adenoma displayed two pathogenic variants that are highly associated with the adenoma-carcinoma sequence (APC; c.4249_4265delATTATAAGCCCCAGTGA, p.Ile1417SerfsTer4, TP53; c.818G > A, p.Arg273His), but not the other three SSLs.