UBR7 and hepatocellular carcinoma: Furthermore, by comparing the mRNA level of UBR7 in HCC tissues (n = 20) and normal liver tissues (n = 20), we found that the expression of UBR7 was significantly lower in primary tumors than that in normal tissues (Fig. 1D), which is consistent with the putative lower gene copy-number of UBR7 in tumor samples from GISTIC database (Fig. 1E).