In the CETP gene, known for genetic disorders of the HDL metabolism, PAVs were associated with serum apoA1 concentrations (p=6.9×10−5), total HDLC (p=4.0×10−5), and seven other lipid measurements in HDL particles, driven by two low-frequency missense variants, rs5880 and rs1800777 previously associated with low HDLC [73]. The gene discussed is CETP; the disease is hereditary disease.