LIPC and hyperlipidemia due to hepatic triglyceride lipase deficiency: Previously, p.Thr405Met has been identified to cause hepatic lipase deficiency in a compound heterozygous state with another rare p.Ser301Phe mutation in LIPC, causing elevated total cholesterol, triglyceride, and triglyceride-enriched VLDL and LDL particles, followed by premature atherosclerosis [76]; in our GWAS data, also the rs121912502 (p.Ser301Phe) variant was nominally associated (p=0.04) with apoA1 despite low imputation quality (0.37) and low MAF (0.0002).