While association with higher apoA1 and HDLC may seem contradictory to the association with high total cholesterol and hypertriglyceridemia, severe hepatic lipase deficiency is characterized by an increase in apoA1, HDLC, and HDL triglyceride content [77], all seen in our data as well. The gene discussed is APOA1; the disease is hyperlipidemia due to hepatic triglyceride lipase deficiency.