GTF3C5 and angina pectoris: Also, another rare (MAF=0.001) deleterious rs369889499 (p.Tyr347Cys) variant in GTF3C5 was 77-fold enriched in the Finns- and associated with multiple phenotypes, including angina pectoris (p=9.20×10−5) and ischemic heart disease (p=6.10×10−4).