PAVs in the hypercholesterolemia-associated APOE gene were associated with apoB (p=3.5×10−4), total HDLC (p=8.0×10−4), and total cholesterol and cholesterol esters in LDL particles, with large negative effects observed for the previously reported rare p.Glu57Lys (rs201672011) variant [74]. Here, APOE is linked to familial hypercholesterolemia.