In the UK Biobank WES [9], putative loss-of-function variants (MAF≤1%) in GTF3C5 were associated with CAD (OR 1.89, 95% CI 1.26–2.84, p=0.0022; significant after correction for 12 lead genes, but not for three investigated phenotypes; Additional file 1: Table S10). This evidence concerns the gene GTF3C5 and coronary artery disorder.