PAVs in CYP3A43 were associated with LDL cholesterol esters in WGS and replicated in WES; CYP3A43 was the only gene with evidence of association with clinical outcome in our WES-WGS data (SKAT p=0.004 for DKD, rank 43/17,578 genes). This evidence concerns the gene CYP3A43 and diabetic kidney disease.