CXCR4 and SDF-1 are indicators of more aggressive papillary thyroid cancer types and act as key regulators of local and distant metastasis in various types of thyroid cancer, leading to a poorer prognosis in CXCR4/SDF-1-positive cancers [10, 13, 25]. This evidence concerns the gene CXCR4 and thyroid gland papillary carcinoma.