We applied the novel assay to analyze VILIP-1 concentrations in six different diagnostic groups including AD, behavioral variant frontotemporal dementia (bvFTD), PD spectrum (including Parkinson’s disease (PD), Parkinson’s disease dementia (PDD), and dementia with Lewy bodies (DLB)), amyotrophic lateral sclerosis (ALS), Creutzfeldt-Jakob disease (CJD), and non-neurodegenerative controls (Con). The gene discussed is VSNL1; the disease is Alzheimer disease.