In addition, ERβ modulates TNFα/nuclear factor κB (NF-κB) signaling, epithelial-mesenchymal transition, reactive oxygen species (ROS) signaling, IL-6/Janus kinase (JAK)/signal transducer activity, activator of transcription (STAT)3 signaling, and hypoxia signaling in ectopic lesions to mediate endometriosis progression [30]. This evidence concerns the gene ESR2 and endometriosis.