In summary, rES-CSP could inhibit the metastasis of hepatocellular carcinoma in vitro and in vivo, and it was initially determined that rES-CSP may play a critical role in inhibiting tumor growth and metastasis by down-regulating the expression of angiogenesis factor VEGFA and metastasis-associated molecular integrinβ1. This evidence concerns the gene DNAJC5 and neoplasm.