In the present study, CSP I-plus modified rEndostatin (rES-CSP) not only inhibited the migration, invasion of high metastatic hepatocellular carcinoma cell line HCCLM3 in vitro, but also suppressed tumorigenesis and tumor metastasis in nude mice with orthotopic xenograft model of hepatocellular carcinoma HCCLM3-Luc. Here, DNAJC5 is linked to hepatocellular carcinoma.