In the study, CSP I-plus modified rEndostatin (rES-CSP) down-regulated the expression of vascular endothelial growth factor VEGFA and metastasis-associated molecule integerβ1 in HCCLM3 and nude mice with orthotopic xenograft model of hepatocellular carcinoma HCCLM3-Luc. This evidence concerns the gene VEGFA and hepatocellular carcinoma.