In 51 pairs of L_cancer patients, compared with adjacent cancer tissues, the expression of DAND5, SMPD1, KNG1, NKPD1, and CYP11A1 were found to be down-regulated in cancer tissues (two-tailed paired t-test; all P < 0.05, Fig. 10A–E). The gene discussed is SMPD1; the disease is cancer.