Moreover, in 51 pairs of R_cancer patients, compared with adjacent cancer tissues, the expression of LPO, METTL11B, and PTGS2 were found to be up-regulated, and ZC3H12C and MOCS1 were down-regulated in cancer tissues (two-tailed paired t-test; all P < 0.05, Fig. 10F–J). The gene discussed is PTGS2; the disease is cancer.