The L_cancer patient prognosis features and risk score were calculated as: KNG1 × 0.621 + CYP11A1 × 0.600 + SMPD1 × 1.370 + DAND5 × 0.859 + NKPD1 × 0.721 + RP11-59D5_B.2 × 0.568 + CTD-2184C24.2 × 0.514 + RP11-680F8.3 × 0.517 − RP11-51F16.9 × 0.731 + CTD-2012K14.8 × 0.765 (Fig. 6A, B). This evidence concerns the gene SMPD1 and cancer.