To exclude the effect of confounding factors, we used multifactorial logistic regression to analyze the relationship between CRP and other related factors and hypertension, and the results showed that BMI (OR = 1.01,95%CI:1.01–1.19), elevated CRP (OR = 2.13,95%CI:1.14–3.99), diabetes mellitus (OR = 2.68,95% CI:1.24–5.79) were positively associated with hypertension (P < 0.05), statin use was a protective factor for hypertension (OR = 0.49, 95% CI: 0.25–0.94, P < 0.05), and age, gender, Chronic obstructive pulmonary disease and asthma were not significantly associated with hypertension (P > 0. This evidence concerns the gene CRP and diabetes mellitus.