In another study of CRP and hypertension in Japanese men [16], 2991 male workers without hypertension were evaluated, and the risk ratio (HR) for the occurrence of hypertensive events was estimated based on the quartiles of CRP, and 579 (19.4%) subjects developed hypertension during the 5-year follow-up period, and the incidence of hypertension increased with increasing levels of CRP, and the HR increased significantly with increasing CRP levels. This evidence concerns the gene CRP and hypertensive disorder.