Compared with the Lupus + sh-HOXA11-OS group, the expression of Cyr61, Beclin-1, and LC3B in the kidney tissue of mice in the control group was significantly increased (P < 0.05), while nephrin and podocin expression was significantly decreased (P < 0.01) after knockdown HOXA11-OS and knockdown miR-124-3p AAVs were injected simultaneously, reversing the effect of HOXA11-OS knockdown and aggravating kidney damage (Fig. 7B, C). Here, NPHS2 is linked to Nephropathy.