After injection of sh-HOXA11-OS AAV, pathological lesions in the kidney tissue of mice in the Lupus + sh-HOXA11-OS group were significantly improved compared with those of mice in the Lupus group; the morphology of glomeruli was relatively normal, there was no obvious stenosis and occlusion of glomerular capillaries, the proliferation of mesangial cells and endothelial cells was reduced, and the number of infiltrated inflammatory cells was also decreased significantly. Here, HOXA11 is linked to systemic lupus erythematosus.