After treatment with both sh-HOXA11-OS and miR-124-3p inhibition AAV, the levels of 24 h urinary protein, BUN, Scr, as well as the levels of anti-dsDNA, ANA, and anti-Sm antibodies in mice were significantly higher than those in the Lupus + sh-HOXA11-OS group (P < 0.05) (Fig. 6A). This evidence concerns the gene BTG3 and systemic lupus erythematosus.