The qRT-PCR and western blot analyses revealed that the expression of Cyr61, Beclin-1, and LC3B in lupus mice was significantly decreased (P < 0.01), while that of nephrin and podocin was significantly increased (P < 0.05) after HOXA11-OS knockdown compared with the control group, suggesting that renal inflammatory lesions were alleviated. The gene discussed is BECN1; the disease is systemic lupus erythematosus.