The levels of 24 h urinary protein, BUN, Scr, as well as anti-dsDNA, ANA, and anti-Sm antibodies in the Lupus + sh-HOXA11-OS group were significantly lower than those in the Lupus group (P < 0.05), while those in the Lupus + miR-124-3p inhibition group were significantly higher (P < 0.05). This evidence concerns the gene HOXA11 and systemic lupus erythematosus.