These results indicate that HOXA11-OS is involved in renal pathological processes and knocking down HOXA11-OS can alleviate renal injury in lupus mice; however, knocking down miR-124-3p may aggravate renal function injury in lupus mice by reversing the effect of HOXA11-OS knockdown (Fig. 6B, C). Here, HOXA11 is linked to systemic lupus erythematosus.