Reduced RBBP4 expression partially reversed the enhanced proliferation, migration, and invasion ability induced by overexpression of KTN1-AS1 (Fig. 6A–D and Supplementary Fig. S4A–D), indicating that the effect of KTN1-AS1 on the malignant behavior of esophageal cancer cells is affected by RBBP4. Here, RBBP4 is linked to esophageal cancer.