In a recent experiment, we demonstrated the following results: (1) serum activates EphA2 and (2) upregulates VE-cadherin expression through increasing nuclear twist expression, (3) which in turn activates the AKT/MMP-2/LAMC2 pathway, (4) contributing to the formation of VM in PCa PC-3 cells25. This evidence concerns the gene CDH5 and posterior cortical atrophy.