By comparing the genomic data of the MSK and ZS-ICC cohorts, a high alteration frequency of KRAS (p = 0.003; p = 0.003 respectively) and RAD51C (p = 0.028, p = 0.02 respectively) was observed in patients with PNI in both cohorts (Fig. 4a). Here, RAD51C is linked to intrahepatic cholangiocarcinoma.