GCK and diabetes mellitus: Four of these variants resided in GCK, five in HNF1A, HNF4A or HNF1B, four in the insulin gene (INS) and one in KCNJ11. Four individuals with variants in the laminin A/C (LMNA, n=1) or wolframin ER transmembrane glycoprotein (WFS1, n=3) genes were diagnosed with syndromic forms of monogenic diabetes.