Finally, we observed a significant negative Spearman correlation (r = −0.4021; p = 0.0376) between the two Down-miRs (i.e. miR-204-5p and miR-199b-5p) and the four Up-genes (i.e. VEGFA, TGFβ1, CCL5 and CXCL2) only in melanoma biopsies progressed after targeted therapies (PD samples) (Fig. 3F, right panel). The gene discussed is VEGFA; the disease is melanoma.