Although CCL18 induces the increased vimentin and decreased E-cadherin, as well as the upregulation of GM-CSF, IL-8, CCL2, and GRO [42], the upregulated levels of IL-8 in breast cancer cell might be not enough to induce the enrichment of cancer stem cell and mediate chemoresistance. This evidence concerns the gene CXCL8 and breast cancer.