Determined by tumor volume (Fig. 6F and Supplementary Fig. 6E) and the tumor cell apoptosis (TUNEL+EPCAM+) (Fig. 6G, H), we found that co-injection of TAMs, NBFs and tumor cells MCF-7 dramatically enhanced the chemoresistance of MCF-7 cells, compared with the mice co-injected with MCF-7 cells and NBFs or MCF-7 cells and TAMs. Here, EPCAM is linked to neoplasm.