Morever, there was a positive correlation between CCL18+ TAMs and CD10+GPR77+ CAFs in different molecular subtypes of tumors, including 178 cases of hormone receptor positive (HR+) and human epidermal growth factor receptor-2 amplification (HER2+), 46 cases of HR-HER2+ and 35 cases of triple-negative breast cancer (TNBC) (Supplementary Fig. 2E). The gene discussed is C5AR2; the disease is triple-negative breast carcinoma.