Since CD10+GPR77+ CAFs induce chemoresistance by secreting IL-6 and IL-8 [3], we examined the production of these cytokines by RT-qPCR in NBFs treated with CM from different tumors and found that chemoresistant tumor CM significantly induced the production of IL-6 and IL-8 (Supplementary Fig. 1E). This evidence concerns the gene C5AR2 and neoplasm.