Interestingly, chemoresistant and chemosensitive tumor CM could not upregulate CD10 and GPR77 expression in MSCs, pericytes, adipocytes, epithelial cells and endothelial cells (Supplementary Fig.1B), while CD10 and GPR77 were abundantly expressed in NBFs treated with chemoresistant tumor CM (Supplementary Fig.1B), which was validated by Western blotting (Fig. 1B and Supplementary Fig. 1C), flow cytometric analysis (Fig. 1C and Supplementary Fig. 1D) and real-time quantitative PCR (RT-qPCR) (Supplementary Fig. 1E). This evidence concerns the gene MME and neoplasm.