RAN and cancer: Kpnα2 and Ran were next investigated in Kpnβ1 pull-down extracts, and results showed that both proteins were pulled down with Kpnβ1 in each of the cell lines, although there were higher levels of Kpnα2 and Ran present in the Kpnβ1 pull-down extracts of cancer cells compared to normal (Fig. 5B).