KPNB1 and cancer: In further interrogation of the list of proteins that bind Kpnβ1 uniquely in cancer cells, a few proteins were identified that are known to play roles in cancer-related processes, for example FUBP1 (Far upstream element-binding protein 1), a DNA-binding protein that regulates transcription of the proto-oncogene c-Myc34, and CCAR1 (Cell division cycle and apoptosis regulator protein 1), a transcriptional coactivator for nuclear receptors that plays a role in regulating cell growth and apoptosis35,36.