Moreover, ETA exerted significant beneficial differences in glucose homeostasis, dyslipidemia, and liver function tests as well as significantly ameliorated NASH and even MS-associated early hepatic fibrosis via the attenuation of the NF-κB/TNF-α/TGF-β1 signaling pathway in the liver; this pathway was activated in HFHF-fed rats. This evidence concerns the gene TNF and metabolic dysfunction-associated steatohepatitis.