Hence, using potent TNF-α antagonists like ETA could effectively manage MS by preventing its progression via the downregulation of the NF-κB/TNF-α/TGF-β1 signaling pathway and treatment of adipocyte dysfunction, impaired glucose utilization, dyslipidemia, hypertension, and obesity as investigated and confirmed in the current study. This evidence concerns the gene TGFB1 and obesity due to melanocortin 4 receptor deficiency.