In CVB3-induced viral myocarditis, IL-37 treatment obviously weakened the upregulation of NLRP3 inflammasomes (NLRP3, ASC, and caspase-1), and the activation of NLRP3 inflammasomes as evidenced by decreased inflammatory mediators (IL-1β and IL-18). This evidence concerns the gene NLRP3 and viral myocarditis.