P2RX1 and acute myeloid leukemia: Therefore, we first overexpressed Bcat1 in P2x1-null AML cells and showed that ectopic overexpression of Bcat1 almost completely rescued the P2X1 loss of function in recipient mice as evidenced by increased leukemic cell frequencies in the peripheral blood (Fig. 3D, E), reduced overall survival (Fig. 3F) and enhanced infiltration in spleens and livers (Fig. 3G, H).