We also measured the Bcat1 mRNA levels in WT, P2x1-null, Pbx3-overexpressing WT or P2x1-null leukemia cells and showed that the Bcat1 mRNA level was significantly downregulated in P2x1-null AML cells, while increased in Pbx3-overexpressing leukemic cells (Fig. S4E). The gene discussed is P2RX1; the disease is acute myeloid leukemia.