Several genes that have been reported to be related to the self-renewal (Creb, Hoxb4, Hoxa9, Myb, Cbx5, Meis1, Bmi1, Hmgb3 and Pbx1) of AML cells were indeed decreased in the P2x1-null LICs, whereas the differentiation gene expression signatures (Gfi1b, Gata2, Cebpe and Cebpg) were increased (Fig. S3F) [4, 38–41]. Here, CREB1 is linked to acute myeloid leukemia.