P2RX1 and cancer: Among the top 10 significantly downregulated pathways according to the Kyoto Encyclopedia of Genes and Genome (KEGG) analyses, P2X1 was associated with the following pathways: valine, leucine and isoleucine metabolism (or branched chain amino acid (BCAA) metabolism); folate biosynthesis; and transcriptional misregulation in cancer (Fig. 3B).