The subnetwork 16 contained 20 cancer genes and 9 breast cancer genes (CDK2, PRLR, CDH1, ERBB3, TP53BP2, SRC, MBIP, KDM1A and SERPINE1) and it was enriched in 12 KEGG pathways including two pathways that are specific to the breast cancer: KEGG cell cycle and KEGG P53 signalling pathway. This evidence concerns the gene SERPINE1 and breast cancer.