Of the 29 HFpEF-associated proteins that were either selected by the LASSO model or validated in the TECOS cohort, five were significant in a meta-analysis of HF hospitalization in CATHGEN and TECOS (Fig. 4, Supplemental Table S9): PSGL-1, SERPINA12, TMSB10, CLSTN2 and VEGFD. This evidence concerns the gene CLSTN2 and hydrops fetalis.