NR3C1 and hydrops fetalis: As decreased left ventricular ejection fraction (LVEF) is a defining clinical manifestation of HF and glucocorticoid stimulation increases cardiac contractility in vitro33, we examined the effect of rs28714259 polymorphism on GR-mediated cardiomyocyte contractility with live movies of beating hiPSC-CM syncytium (Supplementary Movies 1–6).