Even though COX7A1 increased the activity of complex IV in mitochondrial ETC and enhanced TCA cycle, COX7A1 also inhibited mitochondrial dynamics as well as mitochondrial biogenesis and mitophagy via blocking autophagic flux, which might decrease the sensitivity of NSCLC cells to cysteine deprivation-induced ferroptosis. Here, COX7A1 is linked to non-small cell lung carcinoma.