In contrast, our studies demonstrated early defects in anti-tumor effects (Fig. 7a) and anti-tumor IFN-γ production in tumor, TdLNs, and blood of CD8+ T cells in Batf3-deficient animals, even when studying anti-GFP (Batf3-wt) transferred T cells (Fig. 7d–f). This evidence concerns the gene CD8A and neoplasm.