CD4 and neoplasm: Detailed analysis of the tumor microenvironment showed that the early effects on immune cell activation were not dependent on cross-presenting cDC1s since Batf3−/− mice showed similar or higher expression of early activation markers in CD8+ T cells (CD25, CD69), CD4+ T cells (CD25, CD69, Ly6c) and NK cells (CD25) (Supplementary Fig 8b, c).