Further, co-culture with NDV-infected tumor cells resulted in the production of TNF and IFN-γ by (GFP-non-specific) CD4+ T cells (Supplementary Fig. 1f), possibly induced in an Ag-independent or virus Ag-specific manner and mediated by cytokines such as IFN I26,27, which may further amplify the activation of tumor Ag-specific CD8+ T cells. This evidence concerns the gene CD4 and neoplasm.