TNF and neoplasm: Along with endogenous CD8+ T cells (CD45.1−), JEDI CD8+ T cells (CD45.1+) were also present in the tumor and showed a similar pattern of activation and consistently higher expression of IFN-γ, TNF and Tbet than endogenous CD8+ T cells (Supplementary Fig. 6d), implying tumor Ag-specific cross-priming by cDC1s and T cell recruitment to the tumor.