The therapeutic effect of Flt3L+NDV was completely lost in Batf3−/− mice (Fig. 7a), despite similar increase and activation of total cDCs and pDCs in the tumor and TdLN upon Flt3L+NDV treatment (Fig. 7b, c and Supplementary Fig 8a); an increased proportion of cDC2s was observed, possibly to compensate for the lack of cDC1s (Fig. 7b). The gene discussed is BATF3; the disease is neoplasm.