To explore whether PP2Acα deficiency alleviates ALI by preferencing apoptosis over necroptosis, we intraperitoneally injected PP2Acα cKO mice and Cre− mice with the known apoptosis inhibitor z-Vad-fmk 30 min prior to the CCl4 ALI model induction. The gene discussed is PSMB7; the disease is acute respiratory distress syndrome.