Similar to the Panel A, we could not detect differentially abundant clusters between CON and AD in both compartments using the antibody Panel B. Comparing AD-CP macrophages with those in CON-CP revealed increased expression of CD206, CD163, CD91, CD33, CD172a (SIRPα, the receptor of CD47) and Clec12A, whereas CD64, CD68, CD18 and CD47 were downregulated in AD-CP (Fig. 8f). The gene discussed is ITGB2; the disease is Alzheimer disease.