Interestingly, a potent chemotactic factor for myeloid cells, IL-8 (or CXCL8) and a CCR5-ligand MIP-α were both detected at a higher level in AD-CSF, compared to the CON- and HD-CSF, which is well correlated with the finding described above (i.e. Fig. 1) of an increased CCR5 expression on CSF-enriched myeloid cells. This evidence concerns the gene CXCL8 and Alzheimer disease.