The macrophage subsets (cluster 4, 6 and 9) of AD-GFM showed higher expression level of CD172a, CD11b, CD18, Clec12A and the thrombospondin 1 receptor, CD47 (Fig. 8f), suggesting increased phagocytic phenotypes of the infiltrating macrophages detected in AD-GFM, whereas microglia at this late stage of disease were rather a source of chemoattractant for monocytes and macrophages. Here, SIRPA is linked to Alzheimer disease.