As expected, germline BRCA1/2 rates were significantly higher in BRCA-associated cancers (overall 5.5%; ovarian 9.6%; pancreatic 5.2%; breast 4.9%; prostate 4.5%) compared to rates in non-BRCA-associated histologies (1.4%) (P < 0.001, Fishers exact test; Fig. 1). Here, BRCA1 is linked to cancer.