Among the non-BRCA-associated lineages with 500 or more patients, the rate of germline BRCA1/2 prevalence ranged from 2.6% (25/949) in hepatobiliary to 0.5% (3/604) in thyroid, and was 1.7% (77/4474) among patients with non-small cell lung cancer, which was the most common cancer type in our cohort (Supplementary Data 1). The gene discussed is BRCA1; the disease is cancer.