PRKCA and Alzheimer disease: Thus, this AD-associated mutation in PKCα, which enhances the catalytic activity of the enzyme by 30%34, dramatically impaired cognition of mice at 6 months of age when paired with the APPswe transgene (Fig. 6b) and was sufficient to affect learning and memory on its own at 12 months of age (Fig. 3d and Fig. 6c).