PKC isozymes are involved in numerous brain disorders such as glioblastoma, cerebral ischemia, addiction, and neurodegeneration56–59, and their well-characterized effects on Aβ-mediated synaptic depression and phosphorylation of tau have been proposed mechanisms that lead to synaptic damage, neurotoxicity, and cognitive impairment3,4,59. The gene discussed is MAPT; the disease is brain disorder.