The receptor is slowly and partially desensitized after binding, in contrast to the BKB2R which is rapidly desensitized.22Therefore, it has been hypothesized that stimulation of the BKB1R could explain the long duration of angioedema attacks.23Bradykinin and des-Arg9bradykinin are rapidly broken down into inactive metabolites by aminopeptidase P, neutral endopeptidase, dipeptidyl peptidase IV, and angiotensin-converting enzyme.24 Here, ACE is linked to angioedema.