Activation of the IL-6/STAT3 pathway is also reported to drive macrophages toward M2 differentiation in the tumor microenvironment.25 Nevertheless, as a chemokine highly expressed by M1 macrophages, the effects of IL-6 and the related IL-6/STAT3 pathway on macrophage polarization in the AP context remains to be elucidated. The gene discussed is STAT3; the disease is neoplasm.