A. senticosus extract can inhibit RANKL‐induced osteoclastogenesis by inhibiting the RANK signaling pathway, thereby improving bone loss induced by ovariectomy.[34] In addition, several studies have shown the ameliorative effects of A. senticosus on RA.[13, 14, 15] ASPS is one of the most important active components of A. senticosus. This evidence concerns the gene TNFRSF11A and rheumatoid arthritis.