TOP2A and autism: To validate whether this set of upstream regulators is functionally associated with the autism risk genes found in can4Dn, we identified 70 genes that are shared by the can4Dn genes and a previously published list of validated autism risk genes, which we called the Satterstrom genes (8) (Satterstrom-can4Dn), and performed a protein-protein interaction (PPI) analysis to identify associations among the 15 upstream regulators shared by SFARI genes and can4Dn genes, Top2a, and the Satterstrom-can4Dn genes (fig.