TOP2A and inflammatory bowel disease: To examine this hypothesis, we conducted a ChIP-qPCR experiment to compare the relative fold enrichment of H3K27me3 in the promoter regions of zebrafish orthologs of the 13 highest-ranking Satterstrom genes (8) (table S2) versus 8 high-confidence inflammatory bowel disease (IBD) risk genes as controls (table S3) (55) upon Top2a inhibition.