EZH2 and autism: In addition, while TOP2A binding peaks alone are not enriched for autism risk genes (Fig. 7B, first column), overlapping TOP2A binding peaks with EZH2, SUZ12, and H3K27me3 binding peaks enriched their selective targeting to autism risk genes and can4Dn but not to can4Up and the neurodegenerative disorder gene sets (Fig. 7B).