BDNF and lung cancer: It was reported that BDNF binds to tyrosine kinase B (TrkB) receptor or P75 leads to the activation of PI3K/AKT, RAS/ERK, AMPK/ACC, PLC/PKC and JAK/STAT signalings [46,47], which resulting in tumorigenesis and progression of malignancies, including breast cancer [48], lung cancer [49] and neuroblastoma cancer [50].