It is possible that ceruloplasmin, albumin, IgA, IgG, transferrin, and haptoglobin are the acute-phase proteins most responsive to abdominal insults such as peritoneal inflammation and infection promoted by the cecal trocarization [38–41], since the horses in the control group showed no changes in acute-phase proteins in plasma and peritoneal fluid over time. Here, TF is linked to infection.