RIC8B and Cognitive impairment: To address the question of whether there is a causal relationship between the upregulation of PirB expression and cognitive impairment as well as synaptic plasticity disorder after CSR, we generated PirB cKO mice by stereotactically injecting adeno-associated virus (rAAV-hSyn-Cre-WPRE-Hgh-pA) into the hippocampal CA1 region of mice in the PirBfl/fl mouse line (Fig. 2a).