To illustrate this point, we have analyzed mutations in droplet-forming proteins, FUS (G156E [49], G187S [50]), TDP-43 (A321V [51], A315T [52]), TAU (P301L [41]), TIA-1 (E384K [53]), hnRNPA2 (D214V [54], D290V [55,56]), UBQLN2 (P506T [57]), which are associated with amyotrophic lateral sclerosis (ALS). The gene discussed is TIA1; the disease is amyotrophic lateral sclerosis.