By revisiting publicly available WGS datasets we showed that both the APOBEC3 and A3B‐specific enrichment scores are significantly elevated in head/neck (nasal) MMs, despite the limited number of cases, and that A3B is not only overexpressed at the protein level, as indicated by IHC, but may also contribute to the overall heightened mutational burden in these tumours. This evidence concerns the gene APOBEC3B and neoplasm.