While aggressive Ph‐like ALL subtypes appeared to be enriched in responding samples, identification of biomarkers predicting SM response was challenging and expression levels of neither cIAP1/2, XIAP nor RIPK1 were shown to be predictive (McComb et al, 2016; Richmond et al, 2016; Aguadé‐Gorgorió et al, 2020; Zinngrebe et al, 2020). This evidence concerns the gene XIAP and acute lymphoblastic leukemia.