TNF and acute lymphoblastic leukemia: To our surprise, inhibition of TNFα using the monoclonal antibody Adalimumab (Humira) did not reduce apoptosis or caspase‐8 activation by the SM‐drug combination in LOUCY (Fig EV1A and B), or apoptosis in NALM‐6 (Fig EV1C and D) or primary ALL samples (Fig EV1E), while it efficiently blocked apoptosis induced by the TNFα plus LBW242 combination (Fig EV1A and D).