In the resistant ALL cell lines NALM‐6 and LOUCY, the RIPK1‐inhibitor Necrostatin‐1 (Nec‐1) was unable to inhibit apoptosis induction by SM in combination with VCR, while as a positive control, Nec‐1 significantly reduced apoptosis initiated by TNFα plus LBW242 (Figs 2A and EV1E and F). Here, PCSK1 is linked to acute lymphoblastic leukemia.