In summary, our data indicate that SM in combination with chemotherapy‐induced cell death in r/r ALL independently of cIAP‐1/2 degradation as well as RIPK1, NF‐κB and TNFα signaling, indicating that other mechanisms are at play as compared to SM‐sensitive ALL cells (Loder et al, 2012). This evidence concerns the gene BIRC2 and acute lymphoblastic leukemia.