TARDBP and amyotrophic lateral sclerosis: In humans, prion-like proteins have been linked mechanistically to amyotrophic lateral sclerosis (ALS) and other neurological/neuromuscular disorders, in particular the RNA-binding proteins FUS, EWSR1, TAF15, TDP43 and hnRNPA2 (Chen et al., 2019; Picchiarelli & Dupuis, 2020; Smethurst, Sidle & Hardy, 2015).