MAPT and early-onset autosomal dominant Alzheimer disease: Disparities in FC and amyloid spread as a function of sex and race are an unexplored potential mechanism behind risk and burden disparities in study populations.63,64 In the future, including tau trajectories as well as other structural and pathological changes such as neuroinflammation that appears to occur early in Alzheimer’s disease will help assess the overall aetiology of preclinical disease and conclusively determine driving factors for the dynamic changes in FC.