Some of the regions we identified as significant in preclinical amyloid accumulation have also been shown to accumulate tau in Alzheimer’s disease.65,66 While Amyloid-β and tau follow different trajectories, Amyloid-β triggers the conversion of tau from a normal to a toxic state67 and facilitates tau spread from the locus coeruleus and entorhinal cortex to the cortex. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.